- K05B2.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in several structures, including head muscle; interfacial epithelial cell; pharyngeal muscle cell; rectal gland cell; and vulva. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Is predicted to encode a protein with the following domains: N-terminal RASSF family; Ras association (RalGDS/AF-6) domain; and Ubiquitin-like domain superfamily. Is an ortholog of human RASSF7 (Ras association domain family member 7).
- gfl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable chromatin binding activity and histone binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is an ortholog of human YEATS4 (YEATS domain containing 4).
- znf653 [Search on AGR]
Homo sapiens Enables AF-2 domain binding activity and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of nucleic acid-templated transcription. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
- frm-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in PVDL and PVDR. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Human FRMPD4 enables phosphatidylinositol-4,5-bisphosphate binding activity. Is predicted to encode a protein with the following domains: WW domain; Ras association (RalGDS/AF-6) domain; FERM central domain; FERM superfamily, second domain; FERM/acyl-CoA-binding protein superfamily; Ubiquitin-like domain superfamily; PDZ superfamily; Band 4.1 domain; and PDZ domain. Is an ortholog of human FRMPD1 (FERM and PDZ domain containing 1); FRMPD3 (FERM and PDZ domain containing 3); and FRMPD4 (FERM and PDZ domain containing 4).
- plc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1).
- Raph1 [Search on AGR]
Rattus norvegicus Predicted to be involved in signal transduction. Predicted to act upstream of or within axon extension. Predicted to be located in several cellular components, including cell leading edge; cytosol; and nuclear body. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
- Zfp653 [Search on AGR]
Rattus norvegicus Predicted to enable AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Orthologous to human ZNF653 (zinc finger protein 653); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
- Esrrg [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including AF-2 domain binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and estrogen response element binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ESRRG (estrogen related receptor gamma); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- Ppargc1b [Search on AGR]
Rattus norvegicus Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- mig-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1).