Cacnb2 [Search on AGR]
Homo sapiens This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Cacna1b [Search on AGR]
Rattus norvegicus Enables high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including calcium ion import; regulation of calcium-dependent activation of synaptic vesicle fusion; and response to testosterone. Located in axon terminus; dendritic shaft; and neuronal cell body. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.