Naga [Search on AGR]
Homo sapiens NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
Naga [Search on AGR]
Rattus norvegicus Predicted to enable alpha-N-acetylgalactosaminidase activity and protein homodimerization activity. Predicted to be involved in carbohydrate catabolic process and glycolipid catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase); PARTICIPATES IN globoside metabolic pathway; INTERACTS WITH (+)-schisandrin B; 4,4'-sulfonyldiphenol; aconitine.