acr-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and positive regulation of translation. Located in neuron projection. Expressed in AVE; DVB; cholinergic neurons; somatic nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in lung disease (multiple); nicotine dependence; and stomach cancer. Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).