encodes, by alternative splicing, three isoforms of a putative HMG-box transcription factor orthologous to human SOX1 (OMIM:602148
), SOX2 (OMIM:184429
, mutated in syndromic anophthalmia), and SOX3 (OMIM:313430
, mutated in hypopituitarism), and paralogous to SOX-3; SOX-2 is required for normal embryonic and larval viability, fertility, egg-laying, locomotion, and normally rapid growth; SOX-2 is expressed in larval and adult hypodermis and neurons; the sox-2
gene contains a predicted pan-neuronal regulatory motif.