sox-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron fate specification. Predicted to be located in nucleus. Expressed in several structures, including AWC-ON; head neurons; hypodermis; neuroblasts; and rectal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including X-linked panhypopituitarism; carcinoma (multiple); and syndromic microphthalmia 3. Is an ortholog of human SOX2 (SRY-box transcription factor 2).