Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus.
debra (dbr) encodes a transcriptional coactivator of various transcription factors, including the products of ci and dl. It contributes to developmental patterning, long-term memory, and cellular proliferation.
Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity.
cubitus interruptus (ci) encodes a Zn-finger family of transcription factor. It contributes to Hedgehog (Hh) signaling pathway that is involved in pattern formation and growth control. The product of ci undergoes limited proteolysis to be converted into a truncated form that function as a transcription repressor in the absence of the ligand encoded by hh but is converted into a full-length transcription activator in the presence of the product of hh.
hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways.
Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; and Ribosomal protein/NADH dehydrogenase domain. Is an ortholog of C. elegans T09A5.5.
roadkill (rdx) encodes a protein that functions as a substrate recognition component of Cul3-based E3 ubiquitin ligase complexes. It regulates the Hedgehog signaling pathway by promoting the degradation of the transcription factor encoded by ci.
Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; and Ribosomal protein/NADH dehydrogenase domain. Is an ortholog of C. elegans mrps-25.
Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; and Ribosomal protein/NADH dehydrogenase domain.