Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
Involved in several processes, including chemosensory behavior; cilium assembly; and response to alkaline pH. Located in axon; dendrite; and neuronal cell body. Expressed in neurons. Is an ortholog of human CLUAP1 (clusterin associated protein 1).
PHENOTYPE: Mice homozygous for a single point mutation exhibit decreased total retinal thickness, thin retinal outer nuclear layer, dye leakage from retinal vessels, reduced electroretinogram responses, and retinal photoreceptor degeneration. Mice homozygous for another null allele exhibit male infertility. [provided by MGI curators]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes. Mice homozygous for a different knock-out allele exhibit protection from I/R-induced retinal ganglion cell loss. [provided by MGI curators]
Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of dauer larval development; and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including cuticle; excretory system; interfacial epithelial cell; neurons; and vulval cell. Is an ortholog of human PTCHD3 (patched domain containing 3 (gene/pseudogene)).
Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons. Is an ortholog of human KIFAP3 (kinesin associated protein 3).
Enables protein serine/threonine kinase activity. Involved in cilium organization; protein localization; and regulation of non-motile cilium assembly. Located in neuronal cell body and plasma membrane bounded cell projection. Expressed in lateral ganglion and neurons. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Is an ortholog of human MAK (male germ cell associated kinase).