Him [Search on AGR]
Drosophila melanogaster Holes in muscle (Him) encodes a protein that is expressed in developing mesoderm and myoblasts, as well as in pericardial cells. It binds the transcriptional corepressor encoded by gro to inhibit both muscle differentiation and Mef2 product activity. Him transcription is regulated by Notch signaling and the products of twi and tin.
xpf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity. Involved in DNA damage response; meiotic nuclear division; and regulation of multicellular organismal development. Predicted to be part of nucleotide-excision repair factor 1 complex. Expressed in body wall musculature; embryonic cell; germ cell; and neurons. Used to study Cockayne syndrome; Fanconi anemia; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group Q; XFE progeroid syndrome; and polyneuropathy due to drug. Is an ortholog of human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit).