kcc-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables potassium:chloride symporter activity. Involved in chloride transport; potassium ion transport; and regulation of GABAergic synaptic transmission. Predicted to be located in plasma membrane. Expressed in body wall musculature; egg-laying apparatus; hermaphrodite distal tip cell; intestine; and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; agenesis of the corpus callosum with peripheral neuropathy; and epilepsy (multiple). Is an ortholog of human SLC12A4 (solute carrier family 12 member 4); SLC12A5 (solute carrier family 12 member 5); and SLC12A7 (solute carrier family 12 member 7).