Acan [Search on AGR]
Rattus norvegicus Enables calcium ion binding activity. Involved in several processes, including chondroblast differentiation; response to acidic pH; and response to glucose. Located in extracellular space; neuronal cell body; and perineuronal net. Used to study degenerative disc disease. Biomarker of congestive heart failure; degenerative disc disease; osteoarthritis; and status epilepticus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan); INTERACTS WITH (S)-nicotine; 2,3,7,8-Tetrachlorodibenzofuran; 2-amino-2-deoxy-D-glucopyranose.