mpk-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Expressed in F cell; U cell; germ line; gonad; and oocyte. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Noonan syndrome 13; carcinoma (multiple); and childhood pilocytic astrocytoma. Is an ortholog of human MAPK1 (mitogen-activated protein kinase 1).