encodes a protein containing DnaJ and Myb domains that is orthologousto the mammalian ZRF1/MIDA1/MPP11/DNAJC2 family of ribosome-associated molecular chaperones; in C. elegans, dnj-11
functions to regulate asymmetriccell division and mitotic spindle orientation in the NSM neuroblast andsubsequently the apoptotic death of the NSM sister cell; in regulatingNSM sister cell death, DNJ-11 functions together with CES-2 to negativelyregulate ces-1
transcription in the NSM lineage; in addition to its rolein NSM lineage cell fate, dnj-11
activity is also required generally for embryonic development, growth, reproduction, body morphology, and vulval development; a DNJ-11::GFP reporter fusion is expressed in nearly all somatic cells of embryos, larvae, and adults, and localizes to the cytosol; as dnj-11
mutations are maternally rescuable, dnj-11
is also likely expressed in the germline.