vha-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including positive regulation of apoptotic process involved in development; positive regulation of neurotransmitter secretion; and regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Expressed in excretory pore; hypodermal cell; muscle cell; neurons; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Is an ortholog of human ATP6V1B2 (ATPase H+ transporting V1 subunit B2).