Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Nuclear protein Es2 and Nuclear protein DGCR14/ESS-2. Is an ortholog of C. elegans ess-2.
PHENOTYPE: This locus controls expression of the b allele of Es5 in plasma. The o allele in M. m. molossinus prevents expression of ES5B; the a allele in C57BL/10, SK/Cam and NMRI/Fr allows expression of ES5B. The a allele is dominant. The o allele has no effect onES5A or enzymes encoded by Es2, Es7 or Es11 [provided by MGI curators]