- C44B11.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in canonical NF-kappaB signal transduction; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of neurogenesis. Is an ortholog of human FAIM (Fas apoptotic inhibitory molecule).
- LRR [Search on AGR]
Drosophila melanogaster Leucine-rich repeat (LRR) encodes a protein that can negatively regulate NF-kappaB signaling.
- Rtkn2 [Search on AGR]
Homo sapiens Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of NIK/NF-kappaB signaling. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
- Nf-YA [Search on AGR]
Drosophila melanogaster Nuclear factor Y-box A (Nf-YA) encodes a subunit of the nuclear transcription factor Y (NF-Y), also known as the CCAAT motif-binding factor (CBF). It is involved in eye and thorax development via gene expression regulation.
- Nf-YC [Search on AGR]
Drosophila melanogaster Nuclear factor Y-box C (Nf-YC) encodes a transcription factor involved in axon guidance.
- Rela [Search on AGR]
Homo sapiens NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- Ankrd42 [Search on AGR]
Homo sapiens Predicted to enable NF-kappaB binding activity. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity and positive regulation of cytokine production involved in inflammatory response. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
- Trim52 [Search on AGR]
Homo sapiens Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
- Tonsl [Search on AGR]
Homo sapiens The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]