clh-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables voltage-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in egg-laying apparatus; epithelial cell; excretory cell; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Thomsen disease; idiopathic generalized epilepsy 11; and renal tubular transport disease (multiple). Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2).