- Cd55 [Search on AGR]
Homo sapiens This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
- hsp-90 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including ATP hydrolysis activity; nuclear glucocorticoid receptor binding activity; and protein phosphatase 5 binding activity. Involved in several processes, including determination of adult lifespan; protein export from nucleus; and protein stabilization. Located in perinuclear region of cytoplasm and protein-containing complex. Expressed in several structures, including excretory system; germ line; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease; autoimmune disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human HSP90AB1 (heat shock protein 90 alpha family class B member 1).
- age-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
- daf-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables nuclear receptor activity; sequence-specific DNA binding activity; and steroid hormone binding activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and positive regulation of dauer larval development. Located in nucleus. Expressed in several structures, including gonad; neurons; pharyngeal muscle cell; somatic gonad precursor; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); autosomal recessive limb-girdle muscular dystrophy type 2B; carcinoma (multiple); and lung disease (multiple). Is an ortholog of human VDR (vitamin D receptor).
- daf-38 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein heterodimerization activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in chemosensory neurons and head neurons.
- daf-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including determination of adult lifespan; response to oxygen-containing compound; and signal transduction. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ADLL; ADLR; ASHL; and ASHR.
- daf-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables BMP binding activity. Involved in several processes, including defense response to other organism; regulation of BMP signaling pathway; and regulation of anatomical structure morphogenesis. Located in plasma membrane. Expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; artery disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human ACVR2B (activin A receptor type 2B).
- daf-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of dauer larval development; and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Expressed in several structures, including cuticle; excretory system; interfacial epithelial cell; neurons; and vulval cell. Is an ortholog of human PTCHD3 (patched domain containing 3 (gene/pseudogene)).
- daf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable activin binding activity; activin receptor activity, type I; and transforming growth factor beta receptor activity. Involved in several processes, including dauer entry; determination of adult lifespan; and response to bacterium. Predicted to be located in plasma membrane. Predicted to be part of activin receptor complex. Expressed in several structures, including distal tip cell; ganglia; inner labial sensillum; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glaucoma (multiple); and hypertension (multiple). Is an ortholog of human ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1).