Involved in several processes, including chemotaxis; cilium organization; and olfactory behavior. Acts upstream of or within cilium assembly and intraciliary retrograde transport. Located in non-motile cilium. Part of intraciliary transport particle B. Expressed in neurons and oxygen sensory neurons. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; and asphyxiating thoracic dystrophy 5. Is an ortholog of human WDR19 (WD repeat domain 19).
The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.
Predicted to be involved in intraciliary retrograde transport. Is an ortholog of C. elegans dyf-2. In C. elegans, dyf-2 is involved in several processes, including chemotaxis; cilium organization; and olfactory behavior.