Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is an ortholog of human DCTN1 (dynactin subunit 1).
Involved in chromosome segregation; establishment of mitotic spindle orientation; and single fertilization. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. Part of dynactin complex. Expressed in body wall musculature; neurons; seam cell; somatic nervous system; and tail. Is an ortholog of human DCTN2 (dynactin subunit 2).