let-767 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)] activity. Involved in several processes, including female genitalia development; long-chain fatty acid biosynthetic process; and steroid metabolic process. Located in apical cortex and endoplasmic reticulum. Expressed in hypodermis; intestine; and pharynx. Used to study obesity. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and Alzheimer's disease. Is an ortholog of human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).