hmgr-1

Caenorhabditis elegans

Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Predicted to be involved in isoprenoid biosynthetic process and sterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and peroxisomal membrane. Expressed in excretory cell; intestine; non-striated muscle; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; autosomal recessive limb-girdle muscular dystrophy; intermediate coronary syndrome; and type 2 diabetes mellitus. Is an ortholog of human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).