- Y6B3B.9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Is an ortholog of human LAS1L (LAS1 like ribosome biogenesis factor).
- Ca-1D [Search on AGR]
Drosophila melanogaster Ca[2+]-channel protein alpha[[1]] subunit D (Ca-alpha1D) encodes the pore-forming alpha subunit of an L-type voltage-gated Ca[2+] channel expressed in neurons. It mediates Ca[2+] influx, affecting action potential generation and muscle contraction.
- Calx [Search on AGR]
Drosophila melanogaster Na/Ca-exchange protein (Calx) encodes a Na-Ca exchanger involved in phototransduction and response to endoplasmic reticulum stress.
- ca [Search on AGR]
Drosophila melanogaster claret (ca) encodes a protein that is required for wild-type eye color. ca mutant flies show a wine-red eye color.
- Sln [Search on AGR]
Homo sapiens Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
- Slc8a1 [Search on AGR]
Homo sapiens In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
- ncx-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium:sodium antiporter activity; calmodulin binding activity; and metal ion binding activity. Predicted to be involved in metal ion transport. Predicted to be located in membrane. Expressed in dorsal nerve cord; head neurons; phasmid neurons; and ventral nerve cord.
- PMCA [Search on AGR]
Drosophila melanogaster plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx.
- Rps4x [Search on AGR]
Mus musculus PHENOTYPE: Rps4x, Ube1x, and Zfx are subject to X-inactivation in mouse but not in human, suggesting that Turner syncrome may be in part due to insufficiency in these gene products. [provided by MGI curators]
- Nrxn1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+). [provided by MGI curators]