madd-2 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse]
Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9). Exhibits protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Is involved in several processes, including cell morphogenesis; cell projection assembly; and protein ubiquitination. Localizes to several cellular components, including the cell leading edge; neuronal cell body; and striated muscle dense body. Is expressed in several structures, including anchor cell; intestinal cell; neurons; ray precursor cell; and vulval muscle, type 2. Human ortholog(s) of this gene are implicated in several diseases, including Bardet-Biedl syndrome 11; Opitz-GBBB syndrome; and autosomal recessive limb-girdle muscular dystrophy type 2H.