hel-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; nuclear mRNA surveillance; and positive regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human DDX39A (DExD-box helicase 39A).