hda-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable histone deacetylase activity and transcription corepressor activity. Involved in DNA protection and nematode male tail tip morphogenesis. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Expressed in distal tip cell; gonadal sheath cell; nerve ring; pharynx; and uterus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); intrahepatic cholestasis of pregnancy; and pulmonary hypertension. Is an ortholog of human HDAC3 (histone deacetylase 3).