atf-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Part of chromatin. Expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; colorectal cancer; and schizophrenia. Is an ortholog of human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5).