atgl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable triglyceride lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Located in lipid droplet. Expressed in intestine; nerve ring; and ventral nerve cord. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 10; liver disease (multiple); and type 2 diabetes mellitus. Is an ortholog of human PNPLA2 (patatin like phospholipase domain containing 2) and PNPLA3 (patatin like phospholipase domain containing 3).