dyn-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Involved in several processes, including embryo development; endocytosis; and necroptotic process. Located in several cellular components, including plasma membrane; plasma membrane bounded cell projection; and spindle microtubule. Expressed in several structures, including neurons; non-striated muscle; pharyngeal-intestinal valve; rectal valve cell; and somatic nervous system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and developmental and epileptic encephalopathy (multiple). Is an ortholog of human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3).