Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of several human genes including H3C1 (H3 clustered histone 1); H3C3 (H3 clustered histone 3); and H3C4 (H3 clustered histone 4).
Enables myosin binding activity. Involved in locomotion; regulation of cytoskeleton organization; and striated muscle myosin thick filament assembly. Located in M band and striated muscle myosin thick filament. Expressed in anal depressor muscle; body wall musculature; and pharyngeal muscle cell.
Enables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell.
Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein).