Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and regulation of multicellular organismal process. Located in neuron projection and postsynaptic membrane. Expressed in several structures, including body wall musculature; copulatory spicule; enteric muscle; oblique male muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Predicted to enable transferase activity. Involved in PERK-mediated unfolded protein response and innate immune response. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).
Predicted to enable metalloendopeptidase activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in extracellular region.
Involved in oocyte maturation and positive regulation of smooth muscle contraction. Predicted to be located in cytoplasm; cytoskeleton; and pseudopodium. Expressed in gonad; oocyte; and sperm.