age-1 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse]
Is an ortholog of human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) and PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). Is predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Is involved in several processes, including dauer entry; insulin receptor signaling pathway involved in determination of adult lifespan; and regulation of synaptic growth at neuromuscular junction. Localizes to the cytoplasm; non-motile cilium; and phosphatidylinositol 3-kinase complex. Is expressed in amphid neurons; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene are implicated in several diseases, including CLOVES syndrome; epidermal nevus; and gastrointestinal system cancer (multiple).