hlh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in positive regulation of mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Expressed in several structures, including C lineage cell; D lineage cell; I4 neuron; MSaaaapa; and body wall muscle cell. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in congenital myopathy 17 and congenital structural myopathy. Is an ortholog of several human genes including MYF5 (myogenic factor 5); MYF6 (myogenic factor 6); and MYOD1 (myogenic differentiation 1).