Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in axon; perikaryon; and synapse. Expressed in EF neuron and neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; developmental and epileptic encephalopathy 89; and diabetes mellitus (multiple). Is an ortholog of human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2).
Enriched in AFD; muscle cell; and neurons based on RNA-seq studies. Is affected by several genes including unc-30; met-2; and set-25 based on RNA-seq studies.
Is affected by unc-30; hda-2; and nhr-25 based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Coiled-coil domain containing protein 32 and Coiled-coil domain containing 32.
Predicted to enable high-affinity L-arginine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be located in mitochondrion. Is an ortholog of human SLC25A45 (solute carrier family 25 member 45); SLC25A47 (solute carrier family 25 member 47); and SLC25A48 (solute carrier family 25 member 48).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons.
Predicted to enable calcium ion binding activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is an ortholog of human SLC25A25 (solute carrier family 25 member 25).
Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in ADP transport and ATP transport. Predicted to be located in mitochondrial inner membrane. Is an ortholog of human SLC25A25 (solute carrier family 25 member 25).