Enables GTPase activator activity; Roundabout binding activity; and small GTPase binding activity. Involved in cell projection organization; cellular localization; and locomotion. Located in presynaptic membrane. Expressed in nerve ring and neurons. Is an ortholog of human SYDE2 (synapse defective Rho GTPase homolog 2).
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
Predicted to be involved in signal transduction. Is an ortholog of C. elegans syd-1. In C. elegans, syd-1 is involved in cell projection organization; cellular localization; and locomotion.
The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]
Predicted to enable GTPase activator activity. Acts upstream of or within cell migration. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]