Predicted to enable protein serine/threonine kinase activity. Involved in regulation of meiosis I. Located in cytoplasm. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human PLK1 (polo like kinase 1).
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
Is predicted to encode a protein with the following domains: POLO box duplicated region; POLO box domain superfamily; and POLO box domain. Is an ortholog of C. elegans plk-2. In C. elegans, plk-2 is involved in regulation of meiosis I.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-1; plk-2; and plk-3. In C. elegans, plk-1 is involved in organelle organization; positive regulation of nematode male tail tip morphogenesis; and regulation of cell cycle.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans plk-1; plk-2; and plk-3. In C. elegans, plk-1 is involved in organelle organization; positive regulation of nematode male tail tip morphogenesis; and regulation of cell cycle.