Enables G-protein alpha-subunit binding activity. Involved in regulation of gene expression. Expressed in several structures, including accessory cell; amphid neurons; germ line; gonad; and oocyte.
The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Enables enzyme binding activity; phosphatidylinositol phosphate binding activity; and protein self-association. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Expressed in embryonic cell; gonad; and gonadal sheath cell. Is an ortholog of human SNX18 (sorting nexin 18) and SNX33 (sorting nexin 33).
Predicted to enable phosphatidylinositol binding activity. Is an ortholog of C. elegans lst-4. In C. elegans, lst-4 is involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance.
Predicted to enable phosphatidylinositol binding activity. Is an ortholog of C. elegans lst-4. In C. elegans, lst-4 is involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance.