Enables PDZ domain binding activity. Is involved in Wnt signaling pathway, planar cell polarity pathway and digestive tract morphogenesis. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including P5.ppp; P7.paa; egg-laying apparatus; gonad; and neurons. Human ortholog(s) of this gene are implicated in caudal regression syndrome and neural tube defect. Is an ortholog of human VANGL1 (VANGL planar cell polarity protein 1) and VANGL2 (VANGL planar cell polarity protein 2).
Is predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Human ortholog(s) of this gene are implicated in several diseases, including oral squamous cell carcinoma; primary autosomal recessive microcephaly 1; and renal carcinoma. Is an ortholog of human MCPH1 (microcephalin 1).