Enables PDZ domain binding activity. Involved in Wnt signaling pathway, planar cell polarity pathway and digestive tract morphogenesis. Located in apical plasma membrane and basolateral plasma membrane. Expressed in several structures, including P5.ppp; P7.paa; egg-laying apparatus; gonad; and neurons. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Is an ortholog of human VANGL1 (VANGL planar cell polarity protein 1) and VANGL2 (VANGL planar cell polarity protein 2).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).