ttx-7

Caenorhabditis elegans

Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2).

ttx-1

Caenorhabditis elegans

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).

sra-11

Caenorhabditis elegans

Predicted to enable olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception and olfactory learning. Predicted to be located in membrane. Expressed in VC neuron; interneuron; pharyngeal neurons; and ventral ganglion.

wrk-1

Caenorhabditis elegans

Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including SMDVL; body ganglion; head neurons; hermaphrodite distal tip cell; and interfacial epithelial cell.

hen-1

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Involved in dauer larval development and nervous system process. Located in axon and neuronal cell body. Expressed in neurons; pharyngeal muscle cell; and vulva.

ver-1

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in nematode male tail tip morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in intestinal muscle; intestine; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including FLT1 (fms related receptor tyrosine kinase 1); FLT3 (fms related receptor tyrosine kinase 3); and FLT4 (fms related receptor tyrosine kinase 4).

dac-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in thermotaxis. Located in nucleus. Expressed in amphid neurons; cuticular ala; and tail. Is an ortholog of human DACH1 (dachshund family transcription factor 1).

ttx-3

Caenorhabditis elegans

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including olfactory learning; regulation of developmental process; and response to temperature stimulus. Predicted to be located in nucleus. Expressed in head muscle; head neurons; and pharyngeal neurons. Is an ortholog of human LHX9 (LIM homeobox 9).

W04A8.1

Caenorhabditis elegans

Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).

kal-1

Caenorhabditis elegans

Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and syndecan binding activity. Involved in anatomical structure morphogenesis; embryo development; and neuron migration. Located in cell surface. Expressed in several structures, including egg-laying apparatus; excretory cell; nerve ring; neuroblasts; and neurons. Used to study Kallmann syndrome. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Is an ortholog of human ANOS1 (anosmin 1).