Predicted to enable general transcription initiation factor activity. Involved in embryo development; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of chromatin. Expressed in several structures, including germ line. Is an ortholog of human TBPL1 (TATA-box binding protein like 1).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).