Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process and isocitrate metabolic process. Predicted to be located in cytosol; mitochondrion; and peroxisome. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and hematologic cancer (multiple). Is an ortholog of human IDH1 (isocitrate dehydrogenase (NADP(+)) 1).
Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including D-2-hydroxyglutaric aciduria 2; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma (multiple). Is an ortholog of human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).