Predicted to enable tRNA dimethylallyltransferase activity. Involved in determination of adult lifespan and regulation of growth. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Is an ortholog of human TRIT1 (tRNA isopentenyltransferase 1).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).