Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ferroxidase activity; and iron ion binding activity. Involved in determination of adult lifespan; response to hydrogen peroxide; and response to superoxide. Located in mitochondrion. Expressed in amphid neurons; body wall musculature; pharyngeal muscle cell; and spermatheca. Used to study Friedreich ataxia. Human ortholog(s) of this gene implicated in Friedreich ataxia 1 and type 2 diabetes mellitus. Is an ortholog of human FXN (frataxin).
Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in mitochondrial matrix. Expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and pre-eclampsia. Is an ortholog of human ISCU (iron-sulfur cluster assembly enzyme).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).