fat-1

Caenorhabditis elegans

Predicted to enable oxidoreductase activity. Involved in positive regulation of locomotion and unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder.

fat-4

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Expressed in nerve ring and touch receptor neurons. Used to study alcohol use disorder. Is an ortholog of human FADS1 (fatty acid desaturase 1).

cdh-4

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Expressed in several structures, including QL; QR; VD neuron; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Is an ortholog of human FAT1 (FAT atypical cadherin 1); FAT2 (FAT atypical cadherin 2); and FAT3 (FAT atypical cadherin 3).

fat-7

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in fatty acid biosynthetic process and post-embryonic development. Acts upstream of or within intracellular oxygen homeostasis and response to hypoxia. Predicted to be located in endoplasmic reticulum membrane. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Is an ortholog of human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5).

fat-2

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; fatty acid biosynthetic process; and innate immune response. Predicted to be located in membrane.

nhr-80

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons.

fat-3

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including egg-laying behavior; signal release; and system process. Predicted to be located in membrane. Expressed in body wall musculature; head neurons; intestine; pharynx; and tail neurons. Used to study alcohol use disorder and lipid metabolism disorder. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is an ortholog of human FADS2 (fatty acid desaturase 2) and FADS3 (fatty acid desaturase 3).

fat-6

Caenorhabditis elegans

Enables stearoyl-CoA 9-desaturase activity. Involved in innate immune response; long-chain fatty acid biosynthetic process; and post-embryonic development. Predicted to be located in endoplasmic reticulum membrane. Expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Is an ortholog of human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5).

lipl-4

Caenorhabditis elegans

Enables triglyceride lipase activity. Involved in cellular lipid metabolic process; determination of adult lifespan; and positive regulation of macroautophagy. Located in lysosome. Expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J).

glb-16

Caenorhabditis elegans

Predicted to enable oxygen binding activity and oxygen carrier activity. Predicted to be involved in oxygen transport and response to hypoxia. Expressed in head neurons and tail neurons.