Predicted to enable 5'-3' DNA exonuclease activity and 5'-flap endonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to be located in nucleus. Is an ortholog of human EXO1 (exonuclease 1).
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity and phosphoric diester hydrolase activity. Involved in base-excision repair; embryo development; and nematode larval development. Predicted to be located in nucleus. Expressed in hermaphrodite gonad and male gonad. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); prostate carcinoma in situ; and spina bifida. Is an ortholog of human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).