Predicted to enable protein-disulfide reductase activity. Involved in IRE1-mediated unfolded protein response and protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum membrane. Is an ortholog of human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha) and ERO1B (endoplasmic reticulum oxidoreductase 1 beta).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).