erm-1

Caenorhabditis elegans

Enables cytoskeletal anchor activity and structural molecule activity. Involved in several processes, including actin filament organization; nematode larval development; and protein localization to basolateral plasma membrane. Located in actin filament; apical part of cell; and membrane-enclosed lumen. Expressed in several structures, including PVD; excretory canal; germ line; germline precursor cell; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24 and immunodeficiency 50. Is an ortholog of human EZR (ezrin) and MSN (moesin).

F31B12.3

Caenorhabditis elegans

Enriched in GLR; dorso-rectal ganglion; head mesodermal cell; hermaphrodite gonad; and neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; etr-1; and csr-1 based on microarray and RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies.

W04A8.1

Caenorhabditis elegans

Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).

nfm-1

Caenorhabditis elegans

Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including regulation of cellular localization; regulation of gliogenesis; and regulation of hippo signaling. Predicted to be located in several cellular components, including adherens junction; apical part of cell; and filopodium. Expressed in excretory gland cell; gonadal sheath cell; intestinal cell; pharyngeal muscle cell; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).

C41C4.18

Caenorhabditis elegans

Is affected by prg-1; hsf-1; and glp-1 based on RNA-seq studies.

F26D11.15

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and glp-1 based on RNA-seq studies.

W06H8.10

Caenorhabditis elegans

Is affected by cep-1; adr-1; and etr-1 based on RNA-seq studies.

W09H1.7

Caenorhabditis elegans

Is affected by cep-1; adr-1; and dlc-1 based on RNA-seq studies.

ZK616.62

Caenorhabditis elegans

Is affected by emr-1; cep-1; and adr-1 based on RNA-seq studies.

ZK867.11

Caenorhabditis elegans

Is affected by cep-1; camt-1; and etr-1 based on RNA-seq studies.