Enables cystathionine beta-synthase activity; cysteine synthase activity; and pyridoxal phosphate binding activity. Involved in sulfur compound biosynthetic process. Located in cytoplasm. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including homocystinuria; hyperhomocysteinemia; and neural tube defect. Is an ortholog of human CBS (cystathionine beta-synthase).
Predicted to enable cystathionine beta-synthase activity. Predicted to be involved in cysteine biosynthetic process from serine. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including homocystinuria; hyperhomocysteinemia; and neural tube defect. Is an ortholog of human CBS (cystathionine beta-synthase).
Predicted to enable transmembrane transporter activity. Involved in determination of adult lifespan and positive regulation of gonad development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Is an ortholog of several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3); and CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4).
Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of developmental process. Located in basolateral plasma membrane. Expressed in several structures, including body wall musculature; hypodermis; intestine; pharynx; and rectum. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Is an ortholog of several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3); and CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4).
Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of developmental process. Located in basolateral plasma membrane. Expressed in hypodermis and rectum. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Is an ortholog of several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3); and CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).