- atg-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and positive regulation of autophagosome assembly. Predicted to be located in phagophore assembly site. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Is an ortholog of human ATG7 (autophagy related 7).
- aat-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); esophagitis; and glioblastoma. Is an ortholog of human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8).
- atg-4.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type endopeptidase activity. Involved in aggrephagy and protein processing. Located in cytoplasm. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; head muscle; and somatic nervous system. Is an ortholog of human ATG4A (autophagy related 4A cysteine peptidase).
- aat-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8).
- atg-16.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in aggrephagy. Located in cytoplasm. Expressed in embryonic cell; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Is an ortholog of human ATG16L1 (autophagy related 16 like 1).
- atg-4.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cysteine-type endopeptidase activity. Predicted to be involved in autophagy; protein transport; and proteolysis. Predicted to be located in cytoplasm. Expressed in embryonic cell; gonad; and oocyte. Is an ortholog of human ATG4D (autophagy related 4D cysteine peptidase).
- atg-16.2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in defense response to Gram-positive bacterium; gamete generation; and macroautophagy. Located in cytoplasm. Expressed in body wall musculature; embryonic cell; intestine; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Is an ortholog of human ATG16L1 (autophagy related 16 like 1) and ATG16L2 (autophagy related 16 like 2).
- atg-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Atg8-family ligase activity. Involved in macroautophagy. Predicted to be located in cytosol and phagophore assembly site. Is an ortholog of human ATG3 (autophagy related 3).
- atg-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in positive regulation of autophagy. Predicted to be located in phagophore assembly site. Expressed in AIYL and AIYR. Is an ortholog of human ATG2A (autophagy related 2A).
- atg-18 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatidylinositol phosphate binding activity. Involved in several processes, including determination of adult lifespan; gamete generation; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in phagocytic vesicle. Expressed in several structures, including head and tail. Used to study Huntington's disease. Is an ortholog of human WIPI2 (WD repeat domain, phosphoinositide interacting 2).