Predicted to be involved in vesicle-mediated transport. Predicted to be located in intracellular membrane-bounded organelle. Is an ortholog of human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2).
Enables RNA 7-methylguanosine cap binding activity; hydrolase activity, acting on acid anhydrides; and sulfate adenylyltransferase (ADP) activity. Involved in nucleobase-containing compound metabolic process; response to heat; and sulfur compound metabolic process. Located in cytoplasm and nucleus. Is an ortholog of human DCPS (decapping enzyme, scavenger).
Predicted to enable clathrin binding activity. Involved in several processes, including body morphogenesis; clathrin-dependent endocytosis; and nematode larval development. Predicted to be located in intracellular membrane-bounded organelle. Expressed in neurons. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Is an ortholog of human AP2S1 (adaptor related protein complex 2 subunit sigma 1).
Involved in apical protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Is an ortholog of human AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).