Predicted to enable metallopeptidase activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode male tail tip morphogenesis. Acts upstream of or within with a negative effect on plasma membrane fusion. Predicted to be located in plasma membrane. Expressed in excretory gland cell; hypodermis; vulva; and in male. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of human ACE2 (angiotensin converting enzyme 2).
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus. Part of chromatin. Expressed in several structures, including hypodermis; oocyte; spermatocyte; tail; and vulval precursor cell. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Is an ortholog of human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C).
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1).
Enables armadillo repeat domain binding activity. Involved in molting cycle and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including excretory system; gonad; hypodermal cell; tail; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Zellweger syndrome; gonadal dysgenesis (multiple); and primary ovarian insufficiency 7. Is an ortholog of human NR5A2 (nuclear receptor subfamily 5 group A member 2).